Parecoxib Fluconazole

NS AIDs ANTIFUNGALS -FLUCONAZOLE Fluconazole T celecoxib and possibly parecoxib levels Fluconazole inhibits CYP2C9-mediated metabolism of celecoxib and parecoxib Halve the dose of celecoxib and start parecoxib at the lowest dose... 

Fluconazole markedly raises celecoxib levels, whereas ketocona-zole has no effect on celecoxib levels. Fluconazole and ketocona-zole moderately increase the levels of valdecoxib (the main metabolite of parecoxib). Ketoconazole moderately raises etoricoxib plasma levels, but this is unlikely to be of clinical relevance. Fluconazole has no clinically relevant effect on lumiracoxib pharmacokinetics. 

The manufacturer of parecoxib reports a study in which fluconazole increased the plasma levels of valdecoxib (the main metabolite of parecoxib) by 19% and raised its AUC by 62%. Ketoconazole had a similar, but more moderate effect on the levels of valdecoxib (maximum plasma levels increased by 24%, AUC increased by 38%). ... 

---