Paraherquamide stereocontrolled synthesis

C-H alkylation strategy (Scheme 16.3a) [9]. Treatment of indole 16 with Pd(II) according to Trost s C-H alkylation procedure for the syntheses of ibogamine and catharanthine (see Scheme 16.3b) [10] afforded the corresponding heptacyclic compound. After several steps from 18, the synthesis of (+)-paraherquamide B was accomplished. Williams and coworkers also achieved a concise, asymmetric, stereocontrolled total synthesis of stephacidins A and B and notoamide B in 2007 [11]. Additionally, in 2002 and 2003, Corey s group employed an intramolecular C-H alkylation as a key step for the total synthesis of okaramine N, austamide, hydratoaustamide, and deoxyisoaustamide (Scheme 16.3b) [12]. 

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