Panda oleosa

In 1963 a group of Swiss authors (12) isolated zizyphine from Zizyphus oenoplia and recognized isoleucine and proline as components. Two years later Zbiral etal. (13) proposed a complete structure which was later revised (14). Pais et al. (15) in an earlier preliminary report suggested the structure of pandamine which had been isolated from Panda oleosa. This was confirmed in 1966, and the structure of the similarly constituted pandamine was reported (17). Shortly thereafter Tschesche and co-workers (18) reported the structure of an alkaloid of this type scutianine-A from Scutia buxifolia. Since then the number of cyclopeptide alkaloids of known structure has risen to more than sixty, a figure which Klein and Rapoport had envisioned in 1968 (20). The workers at Gif-sur-Yvette and at Bonn have been in the forefront of these researches but others have made important contributions (19-26). 

The winning of the alkaloids is generally achieved by the usual procedures modified to suit the plant source and the properties of the bases. Pais el al. 17), when working with Panda oleosa, moistened the dried and ground plant material with 10% aqueous ammonia and 1% aqueous sodium carbonate followed by extraction with ether. The concentrated extract was shaken with aqueous amidosulfonic acid and the bases regenerated from the aqueous phase by ammonia. An ether solution of the liberated bases frequently yields crystals upon standing but these are virtually always a mixture of bases. 

Dihydroxy-4-methyl- coumarin) (coumarin) 4 -0-Methyl-OTt- Panda oleosa (Pandaceae) COX-1, COX-2... 

Sources Panda oleosa (Pandaceae)-root bark (11,24)... 

Pais, M., F.-X. Jarreau, X. Lusinchi, and R. Goutarel Alcaloides Peptidiques, III (I). Pandamine et Pandaminine, Alcaloides du Panda oleosa Pierre (Pandacees). Ann. 

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