Pancuronium pharmacokinetics

Duvaldestin P, Agoston S, Henzel D, Kersten UW, Desmonts JM. Pancuronium pharmacokinetics in patients with hver cirrhosis. Br J Anaesth 1978 50(11) 1131-6. 

Duvaldestin P, Saada J, Berger JL, D Hollander A, Desmonts JM. Pharmacokinetics, pharmacodynamics, and dose-response relationships of pancuronium in control and elderly subjects. Anesthesiology 1982 56(1) 36 0. 

Pharmacokinetics All agents are given parenterally. Drugs that are metabolized (eg, mivacurium, by plasma cholinesterase) or eliminated in the bile (eg, vecuronium) usually have shorter durations of action than those eliminated by the kidney (eg, doxacurium, pancuronium, tubocurarine). Atracurium clearance involves spontaneous breakdown (Hofmann elimination) to form laudanosine and other products is largely independent of hepatic or renal function. 

Motamed C, Menad R, Farinotti R, Kirov K, Combes X, Bouleau D, Feiss P, Duvaldestin P. Potentiation of mivacurium blockade by low dose of pancuronium. A pharmacokinetic study. Anesfftesiology (2003) 98,1057-62. 

McLeod, K., Watson, M. J. and Rawlings, M. D. (1976) Pharmacokinetics of pancuronium in patients with normal and impaired renal function. Brit. J. Anaesth., 48, 341. 

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