Pancoxin

With regard to the possible use of ivermectin for tsetse and tick control in Africa, a light-stable formulation of MK933, or MK936, the less expensive precursor, might find application for the treatment of domestic and even wild animals if the drug were to be offered in combination with a coccidiostat like Pancoxin (sulphaquinoxaline and pyrimethamine) in a salt lick block (7 ). 

Proprietary Names. It is an ingredient of Amprolmix-UK, Amprol-Plus, Pancoxin, and Supacox. l-(4-Amino-2-propylpyrimidin-5-ylmethyl)-2-methylpyridin-iumchloride hydrochloride Ci4Hi9C1N4,HC1 = 315.2... 

Proprietary Names. It is an ingredient of Pancoxin, Saquadil, Supacox, and Whitsyn S. 

Atnino-2-propyl-5-pyrimidinyl)methyl]-2-picolinium chloride. 1- 4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chloride 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-methylpyridinium chlorid Amprol, Veterinary Amprolio Amprolium Amprovine Corid EINECS 204-458-4 Pancoxin 2-Picolinium, 1-((4-amino-2-propyl-6-pyrimidinyljmethyl)-, chloride Pyridinium, 1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-2-methyl-, chloride. Coccidiostat in veterinary medicine. Also used as an antiparasitic in cattle. Soluble in H2O, MeOH, EtOH, DMF, insoluble in i-PrOH, BuOH, dioxane, Me2CO, EtOAc, CH3CN, isooctane pH 2.6-3.0. 

Acetamido-2-methoxybenzoic acid methyl ester Amprol Plus (veterinary) Benzoic acid, 4-(acetylamino)-2-ethoxy-, methyl ester EINECS 200414-3 Ethopabate Ethyl pabate pancoxin. Coccidiostat, used in poultry, often as Amprol Plus, a combination with amprolium. Crystals mp = 148-149 Xm = 298, 267 nm (A l im 805,365) slightly soluble in H2O, more soluble in organic solvents. 

Synonyms 4"Amino-N-2-quinoxalinyIbenzenesulfonamide 2-sulfanil amido-quinoxaline sulfabenzpyrazine sulphaquinoxaline Trade names Aviochina, Embazin, Pancoxin, Saquadil, Sulquin, Supacox, Whitsyn S... 

Amprolium (Figure 9.7) is a thiamine antagonist. Its oral use as a veterinary drug is permitted for control of coccidiosis in poultry.However, its use as a feed additive is no longer permitted. Authorisation as a coccidiostatic feed additive was withdrawn in 1992 when data requested by SCAN for evaluation of amprolium-containing products (Pancoxin and Pancoxin Plus) were not provided. 

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