PAMAM dendrimers synthesis

Scheme 30.4 Divergent PAMAM dendrimer synthesis starting from a diamine (EDA) core.

P. Singh, U. Gupta, A. Asthana, N.K. Jain, Folate and folate-PEG-PAMAM dendrimers synthesis, charactmzation and targeted anticancer drug delivery potential in tumcr induced mice, Bioconjug. Chem. 19 (11) (2008) 2239-2252. 

Microwave-assisted reactions for polyamidoatnine (PAMAM) dendrimer synthesis was carried out by Lopez-Andarias et al. (2012). The dendrimers were obtained in good yields, with high purity, and near-perfect regioselectivity while multivalent dendrimeric peptides were synthesized via a microwave-assisted Huisgen 1,3-dipolar cycloaddition between azido peptides and dendrimeric alkynes in relatively good yields (46 to 96%) (Rijkers et al., 2005). 

Fig. 2a-c. Dendrimer synthesis using linear building blocks a Vogtle s original procedure b DSM s commercial process c Tomalia s synthesis of PAMAM dendrimers... 

M. Dubber and T. K. Lindhorst, Trehalose-based octopus glycosides for the synthesis of carbohydrate-centered PAMAM dendrimers and thiourea-bridged glycoclusters, Org. Lett., 3 (2001) 4019 1022. 

Figure 7.1 The synthesis of a PAMAM-type dendrimer proceeds from a diamine core [e.g., ethylene diamine (EDA)] by initial addition of the amines to the double bonds of methacrylate. Subsequent reaction of the methyl ester groups with EDA produces a G-0 dendrimer with four pendent amine groups. Another round of methacrylate and EDA additions results in a G-l PAMAM dendrimer containing eight primary amines.

Shukla, S., Wu, G., Chatterjee, M., Yang, W., Sekido, M., Diop, L.A., Muller, R., Sudimack, J.J., Lee, R.J., Barth, R.F., and Tjarks, W. (2003) Synthesis and biological evaluation of folate receptor-targeted boro-nated PAMAM dendrimers as potential agents for neutron capture therapy. Bioconjugate Chem. 14, 158-167. 

Figure 10.2 Schematic illustration of synthesis of (EDA) core PAMAM dendrimers (E 0-2). Higher generations can be obtained by successive reiterations.

Tomalia et al. reported that the surface amines of PAM AM dendrimer can successfully react with methyl esters of other PAMAM dendrimers to afford core-shell tecto-(dendrimer) molecules [65]. Furthermore, they also reported the synthesis of rod-shaped cylindrical dendronized polymers from poly(ethyleneimine) cores without any crosslinking, albeit with the use of excess reagents [58]. These reports lead us to propose a new approach toward hybridized dendrimers and polymers (path C, Figure 15.3). As shown in Scheme 12,... 

Shinkai et al. described the synthesis of dendritic saccharide sensors based on a PAMAM dendrimer labeled with eight boronic acid residues [183]. The dendritic compound showed enhanced binding affinity for D-galactose and d-fructose. The fact that the dendritic boronic acid functions as a saccharide sponge is ascribed primarily to the cooperative action of two boronic acids to form an intramolecular 2 1 complex. When one boronic acid binds a saccharide, its counterpart cannot participate in dimer formation and seeks a guest. 

As outlined in other chapters in this volume, Tomalia et al. first reported the successful well-characterized synthesis of dendrimers in the early 1980s [1], These molecules range in size from 10 A to 130 A in diameter for generation 0 (GO) through generation 10 (G10). In the ideal situation, PAMAM dendrimers are monodispersed spherical conformation with a highly branched three-dimensional structure (Figure 18.1) that provides a scaffold for the attachment of... 

Laboratory Synthesis of Poly(amidoamine) (PAMAM) Dendrimers... 

LABORATORY SYNTHESIS OF POLY(AMIDOAMINE) (PAMAM) DENDRIMERS 591... 

DIVERGENT SYNTHESIS OF PAMAM DENDRIMERS VIA EXCESS REAGENT METHOD PREPARATION OF ESTER TERMINATED PAMAM STAR-BRANCHED PRECURSOR [NH2-(CH2)2 6-NH21 (G = -0.5) STAR-PAMAMICO E) [1]... 

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