Palmostatins Inhibit Downstream Signaling of Ras GTPases

Next it was studied if the observed redistribution of H-Ras to endomembranes leads to decreased signaling of constitutively active oncogenic H-RasG12V [7]. Ras-transformed MDCK-F3 cells show a long and spindle-Uke phenotype and grow in multiple layers with a reduced number of cell-cell contacts. These cells show a loss of contact inhibition, which is accompanied by the loss of E-cadherin 

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Kuhlmann, J., Waldmann, H., Wittinghofer, A., and Bastiaens, P.I.H. (2005) An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. Science, 307, 1746—1752. 

Pechlivanis, M., Kuhlmann, J., Brunsveld, L., Chandra, 

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