Palmitoyl oleoyl phosphatidylethanolamine

Fig. 9. Time-resolved small-angle diffraction from a mixture of l-palmitoyl-2-6leoyl-phosphatidyl-choline and l-hexadecyl-2-oleoyl-phosphatidylethanolamine. Two minutes after mixing of the aqueous dispersions (c,p 0.2) the temperature was raised from 10 to 70 °C, where the latter lipid species forms a hexagonal H phase, while the former stays lamellar. Fusion ofThe two phases and reformation of a lamellar phase is evident from the decay of the hexagonal 1120 reflection. (From Ref. 74, with permission)...

Fig. 21.1 Positive ion MALDI-TOF mass spectra of triolein (a), l-palmitoyl-2-oleoyl-sn-phosphatidylcholine (b), l-palmitoyl-2-oleoyl-sn-phosphatidylethanolamine (c) and 1-pahni-toyl-2-oleoyl-sn-phosphatidylserine (d). In all cases a 0.5 M solution of DHB in methanol was used as matrix and the sample solutions (0.2 mg/ml) diluted 1 1 (v/v) with the matrix. All peaks are marked according to their m/z ratio and the DHB matrix peaks are marked with asterisks...

Kwon et al. used NMR to investigate domain formation in membranes (phosphatidylethanolamine (POPE) and anionic l-palmitoyl-2-oleoyl-s -gZycero-3-phosphatidylglycerol (POPG)) with to cationic peptides. The antimicrobial peptides were (AMP(3)) of the beta-hairpin family of protegrin-1 (PG-1), and two cell-penetrating peptides (CPPs), HIV TAT and penetratin. The NMR showed the extent of the interaction between the bilayers and the peptides. 

One of the oldest methods involves conjugation of HA oligosaccharide to phosphatidylethanolamine by reductive amination via the reducing end of HA. This amphiphilic HA is incorporated into the hilayer of the liposome by mixing with suitable lipid components like cholesterol, l-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and so on, in different ratios. This HA-dioleoylphosphatidylethanolamine was... 

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