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Palladium 1,2-Migration in the Heck Reaction

Chapters 2 and 3 describe an extension of the palladium 1,2-migration in the Heck reaction discovered by Skrydstrup and coworkers. This work was performed in collaboration with Dr. Jean-Philippe Ebran and Dr. Anders Thyboe Lindhardt. [Pg.9]

Even though an interchanged phenylpalladium(II) tosylate complex was obtained, the 1,2-migration proved to be very fast even at room temperature complementing the 1,2-migration from tricoordinated T-shaped palladium(II) complexes observed in the Heck reaction (Chap. 2). [Pg.77]

In order to test the influence of the temperature on the 1,2-migration process, a vinyl triflate was employed. The inherently high levels of reactivity, with respect to the oxidative addition, exhibited by triflate based electrophiles, typically allow the palladium catalyzed reactions to be conducted at lower temperatures. Hence, the Heck reaction of fert-butylvinyl triflate 4 and A-fert-butylacrylamide could successfully be accomplished at room temperature, applying the migrating reaction conditions, resulting in an 83 % isolated yield of 3. More importantly, the... [Pg.56]

See other pages where Palladium 1,2-Migration in the Heck Reaction is mentioned: [Pg.43]    [Pg.48]    [Pg.48]    [Pg.49]    [Pg.51]    [Pg.52]    [Pg.53]    [Pg.57]    [Pg.57]    [Pg.43]    [Pg.48]    [Pg.48]    [Pg.49]    [Pg.51]    [Pg.52]    [Pg.53]    [Pg.57]    [Pg.57]    [Pg.45]    [Pg.68]    [Pg.68]    [Pg.6]    [Pg.43]    [Pg.49]    [Pg.59]    [Pg.67]    [Pg.121]    [Pg.306]    [Pg.173]    [Pg.49]    [Pg.241]    [Pg.51]    [Pg.67]    [Pg.428]    [Pg.498]    [Pg.131]    [Pg.483]    [Pg.483]    [Pg.204]   


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In the Heck reaction

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