Palladium compounds biological applications

Figure 3-2 Some biologically active compounds prepared by application of Heck reactions with asymmetric induction. (The dashed lines indicate bonds formed by palladium-catalyzed coupling).

The volume highlights in the first chapter, written by Lemen and Wolfe, the discovery and the development of original palladium-based catalysts for C(sp )-N bond formation via the coupling of nitrogen nucleophiles and aryl/alkenyl halides and pseudohalides. The authors also report various applications of these transformations to the synthesis of useful compounds, including biologically active molecules and materials. 

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