Palladium-Catalyzed MCRs Involving Isocyanides

Whereas the use of CO as Cj building block in palladium-catalyzed cascade reactions is well established, the application of isoelectronic isocyanides in similar processes is 

SCHEME 3.4 Synthesis of nitrogenated heterocycles via Miinchnone intennediate. 

SCHEME 3.5 Synthesis of x-conjugated oligomers via carbonylative coupling of dialdehydes, di(acyl chloride)s, and imines. 

The original limited scope with regard to the isocyanide was soon overcome. Lang et al. adapted this methodology for the synthesis of benzoxazoles 8 and oxazolines 9 by using 

SCHEME 3.6 Palladium-catalyzed coupling of aryl halides, isocyanide, and amines. 

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