Palladium azido esters

To highlight the utility of the enantioselective azidation further, transformations of the resulting azides were carried out (Scheme 15.11). For example, an a-azido ester could be converted smoothly into a-amino ester by palladium-catalyzed hydrogenolysis, which may provide a useful method for the synthesis of highly substituted cx-amino acid derivatives. On the other hand, the copper-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC), as a click reaction, has been... 

Using azide as the nucleophile, the palladium-catalyzed substitution of 1-alkenylcyclopropyl esters gave l-azido-l-alkeny cyclopropanes, e.g. 12, potential precursors to the corresponding... 

---