Paget disease of bone

Paget disease of bone For treatment of Paget disease of bone where alkaline phosphatase is at least 2 times the upper limit of normal, or those who are symptomatic or at risk for future complications from their disease (alendronate, risedronate, tiludronate) treatment of symptomatic Paget disease (etidronate) treatment of moderate to severe Paget disease (pamidronate). 

Paget disease - The recommended dose in patients with moderate to severe Paget disease of bone is 30 mg daily, given as a 4 hour infusion on 3 consecutive days for a total dose of 90 mg. 

G4. Garnero, P., Fledelius, Ch., Gineyts, E., Serre, C.-M., Vignot, E., and Delmas P. D., Decreased beta-isomerisation of the C-terminal telopeptide of type I collagen alphal chain in Paget disease of bone. J. Bone Miner. Res. 9, 1407-1415 (1997). 

Watts GD, Wymer J, Kovach Ml et al. (2004) Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein. Nat Genet 36, 377-381. 

Kimonis VE, Watts GD. (2005) Autosomal dominant inclusion body myopathy, Paget disease of bone, and frontotemporal dementia. Alzheimer Dis Assoc Disord 19 (Suppl. 1), S44-S47. 

Anovel mutation in the VCP gene (G157R) in a German family with inclusion-body myopathy with Paget disease of bone and frontotemporal dementia. JVcrvc 39(3), 389-391. 

Familial Myopathy, Paget Disease of Bone, and Frontotemporal Dementia 221... 

Kimonis V, Donkervoort S, Watts G. (2011) Inclusion Body Myopathy Associated with Paget Disease of Bone and/or Frontotemporal Dementia Gene GeneT-ests (wwwgenetestsorg) and University of Washington, Seattle. 

Online MendeUan Inheritance in Man (OMIM) http //www3.ncbi.nlm.nih.gov/omim (for inclusion body myopathy, early onset Paget disease of bone, and frontotemporal dementia EBMPFD, MIM 167320). 

Kimonis VE, Kovach Ml, Waggoner B et al. (2000) Clinical and molecular studies in a unique family with autosomal dominant limb-girdle muscular dystrophy and Paget disease of bone. Genet Med 2(4), 232-241. 

Kimonis VB, Fulchiero B, Vesa J, Watts G. (2008) VCP disease associated with myopathy, paget disease of bone and frontotemporal dementia Review of a unique disorder. Biochim Biophys Acta 1782(12), 744-748. 

Badadani M, Watts G, Vesa J et al. (2010) VCP associated inclusion body myopathy and Paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease. PloS ONE 5(10), el3183. 

Calcitonin Pagets disease of bone/ postmenopausal osteoporosis Miacalcin Novartis... 

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