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Packaging nasal formulations

A preformulation package provides essential information on the physicochemical properties of the drug, such as pKa, aqueous solubility, aqueous stability, light stability, and lipophilicity (this may predict potential for binding to plastic/rubber pump components). The pK s of any ionisable groups are particularly important as they affect stability, solubility and lipophilicity and should indicate the optimum pH for the nasal solution. For physiological reasons, formulated products are usually in the range of pH 4.0-7.4. [Pg.496]

See other pages where Packaging nasal formulations is mentioned: [Pg.655]    [Pg.56]    [Pg.60]    [Pg.525]    [Pg.386]    [Pg.1386]    [Pg.988]    [Pg.4299]    [Pg.60]    [Pg.100]    [Pg.339]    [Pg.345]   
See also in sourсe #XX -- [ Pg.492 , Pg.493 , Pg.500 , Pg.501 , Pg.502 , Pg.503 , Pg.504 , Pg.505 , Pg.507 ]



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