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Parylene s use in the medical field is linked to electronics. Certain pacemaker manufacturers use it as a protective conformal coating on pacemaker circuitry (69). The coated circuitry is sealed in a metal can, so that the parylene coating serves only as a backup should the primary barrier leak. There is also interest in its use as an electrode insulation in the fabrication of miniature electrodes for long-term implantation to record or to stimulate neurons in the central or peripheral nervous system, as the "front end" of experimental neural prostheses (70). One report describes the 3-yr survival of functioning parylene-coated electrodes in the brain of a monkey (71). [Pg.442]

DoleJel, B., Adamirova, L., VondrdCek, P. Naprstek, Z. (1989b) In vivo degradation of polymers. II. Change of mechanical properties and cross-link density in silicone rubber pacemaker lead insulations during long-term implantation in the human body. Biomaterials, 10, 387-392. [Pg.177]




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