P-Toluenesulfonamide, derivative

S)-Tetrahydro-l -methyl-3,3-diphenyl-1 H,3H-pyrrolo[1,2-c][1,3,2]oxazabo-role was prepared from (S)-proline in two steps according to the literature procedure4 and purified by bulb-to-bulb distillation (170°C, 0.2 mm). The enantiomeric purity of the intermediate, (S)-a,a-diphenyl-2-pyrrolidinemethanol, was determined to be 99% ee by chiral HPLC analysis of its corresponding N-p-toluenesulfonamide derivative (DIACEL Chiralcel OD column hexane/ethanol, 92/8 1.0 mLVmin Rt(S) 8.6 min Rt(R) 12.8 min). The checkers used the crystalline p-methyloxazaborolidineborane complex (1.84 g, 6.34 mmol) as the catalyst. 

The A,A -bis(p-toluenesulfonamide) derivative of diaza-18-crown-6 was prepared by treating the ditosylate ester of triethylene glycol with the N,N -bis(/7-tolucnesulfonamide) derivative of a diamino ether in base (method... 

Lehn and coworkers used a number of methods to prepare some interesting polyoxaaza macrocycles. These authors used many steps to elaborate a bis(p-toluenesulfonamide) derivative of a diamino ether to form [24]Nf,02 macrocycles (method M-7) (Lehn et al., 1977). In the process, the reaction of a... 

Richman and Atkins (1974, 1978), as well as Vogtle and coworkers, have prepared a number of polyaza-crowns by treating the appropriate per-p-toluenesulfonamide derivative of a polyamine with the ditosylate (dimesylate or dihalide) derivative of an oligoethylene glycol (method N-1) (Buhl-eier et ah, 1977 Rasshofer and Vogtle, 1977 Rasshofer et ah, 1976). They were able to prepare polyaza-crowns with different ring sizes and numbers... 

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See also in sourсe #XX -- [ ]

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