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P-Thymidine

Ciccolini J, Evrard A, Cuq P. Thymidine phosphorylase and fluoropyrimidines efficacy a Jekyll and Hyde story. Curr Med Chem Anticancer Agents 2004 4. 71-S1. [Pg.260]

A practical example of separation of a mixture of a/P-anomers of the mother liquor collected from the commercial-scale synthesis of P-thymidine is shown in Scheme 10.14. PSLC is used as a biocatalyst because this lipase has shown the desired opposite regioselectivity toward the hydrolysis of a- and P-nucleosides. The hydrolysis reaction takes place with excellent selectivity toward the 5 -p-... [Pg.144]

Treatment of thymidine 5 -phosphorodiamidate (54) with pyrophosphate in anhydrous DMF leads to the formation of P -(thymidine-5 )-P -aminotriphosphate (55) in good yield. The compound is sufficiently stable to be purified on DEAE-Sephadex at low temperature. In acid, conversion into TTP is quantitative, but in ammonia, thymidine-5 -phosphoramidate and pyrophosphate are formed. Treatment with alkaline phosphatase cleaves (55) to the phosphoramidate. Nucleophilic attack takes place very easily in anhydrous DMF at ambient temperature, (55) is in equilibrium with (56) and pyrophosphate. [Pg.165]

Crystallise P-thymidine from ethyl acetate, MeOH/Et20 (m 188 ) or H2O (as 2H2O m 189 ). It is soluble in water and hot organic solvents. Thepicrate has m 230 (from EtOH). [Beilstein 24111/1V 1297.]... [Pg.439]

Ml. Marsh, J. C., and Seymour, P., Thymidine catabolism by normal and leukemic human leukocytes. /. Clin. Invest. 43, (1964). [Pg.136]

Cui et al reported the synthesis of a-thymidine and p-thymidine analogues. The authors prepared and optimised a series of 5 -urea-a- and... [Pg.123]


See other pages where P-Thymidine is mentioned: [Pg.215]    [Pg.558]    [Pg.561]    [Pg.561]    [Pg.561]    [Pg.561]    [Pg.1086]    [Pg.144]    [Pg.145]    [Pg.461]    [Pg.439]    [Pg.134]    [Pg.266]    [Pg.312]    [Pg.313]    [Pg.492]    [Pg.492]    [Pg.799]    [Pg.124]   
See also in sourсe #XX -- [ Pg.312 ]




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Thymidine

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