P-Rhodomycinone

The first hybrid anthracyclines were produced by introducing parts of the rhodomycin biosynthetic gene cluster from S. purpurascens into S. galilaeus [49,53]. The transgenic strain produced glycosides of aklavinone, P-rhodomycinone, s-rhodomycinone, 10-decarbomethoxyaklavinone and, as novel products, glycosides of 11-deoxy-b-rhodomycinone (Struct. 6). 

Streptoinjees violaceui A262 mutants p-Rhodomycinone diglycosides epe-lycins A-E obcimycins A-G yel-lamycins A-C alldimycins A-C 89... 

The anthracyclines are pigmented glycosidic antibiotics produced by different strains of Streptomyces. The first of these naturally occurring compounds, P-rhodomycine (la), was isolated by Brockmann and Bauer in 1950 from Streptomycespurpurescens [1]. In the 1950s other rhodomycins were obtained and subsequently their structures were elucidated, mainly by Brockmann [2] and Ollis [3]. The aglycone moieties of these compounds were named anthracyclinones and belong to the various types of rhodomycinones. Examples of representative structures are shown in Fig. 1. 

Prikrylova V, Podojil M, Sedmeia P Vokoun J, Vanek Z, Bradtnikova MG, Kudinova MK. New rhodomycinone from the strain Streptomyces griieoruber 4620. Collect Czech Chcm Commun 1980 45 1991-1995. 

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