P-Ketosulfoxides reduction

The asymmetric synthesis of both enantiomers of various butenolides was reported by Solladie in 1986. based upon his diastereoselective p-ketosulfoxide reduction chemistry (Scheme 4.10) [13], Butenolides are widely found as subunits in many naturally occurring compounds [14-17]. 

The P-ketosulfoxide reduction methodology is also successful with a,P-unsaturated substrates. The asymmetric synthesis of both enantiomers of a range of allylic alcohols was achieved by Solladie from the corresponding a,P-unsaturated p-ketosulfoxide substrates [20, 21]. The reactions were found to be... 

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