P-C Heterocycles Dibenzophosphole Oxides

Recently, C-H activation catalyzed by transition metals has been recognized as a challenging objective in organic synthesis. In 2011, Takai and coworkers established the first example of a Pd(0)-catalyzed C-H phosphorylation reaction in an 

In 2012, Takai and coworkers use a bis(biphenyl)phosphine oxide to synthesize a new phosphine oxide with a chiral phosphine center by dehydrogenative intramolecular cyclization via P-H and C-H bond activation under palladium 

The advantages of this new method include (i) operational simplicity, (ii) direct use of simple starting materials, (iii) excellent functional group compatibility, and (iv) high modularity of the aromatic component to be incorporated. The application of this method to the synthesis of elaborated phosphole derivatives and other heterocyclic compounds is being actively investigated. 

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