P-Adrenergic receptor agonist

The classic example of an asthma pharmacogenetic candidate gene is ADRP2 (Pj-adrenergic receptor). The P -adrenergic receptor agonists, such as the short-acting... 

L-norepinephrine and dopamine are present in some plants and act as agonists for both a- and P-adrenergic receptors [1]. Further plant P-adrenergic receptor agonists include the phenylpropanoid alkaloids L-... 

These are also known as the P-adrenergic receptor agonists. 

The reaction has been employed in several molecules in drug discovery and development. For example, Ikemoto et al. have developed a practical route to a thiazole as part of their efforts toward a kilogram-scale synthesis of a P-adrenergic receptor agonist as a candidate for tihie treatment of obesity. The thiazole ring was assembled by allowing the haloketone and thioamide to react. 

Enantiopure 2-, 3-, and 4-p3uidyloxiranes are key building blocks for the synthesis of several biologically active compounds, such as p-adrenergic receptor agonists or antiobesity drugs [108-110]. Up to now, none of these products could be obtained in a... 

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