P450-dependent monoxygenases

Pinto, A., Abraham, N. G., Mullane, K. M., Cytochrome P450-dependent monoxygenase activity and endothelial-dependent relaxations induced by arachidonic acid. J. Pharmucol. Exp. Ther. 236 (1986),... 

The vast majority of enzyme-catalyzed stereoselective hydroxylations are carried out by the cytochrome P450-dependent monoxygenases [4]. The membrane-bound nature of the majority of these enzymes, together with their functional dependence on the presence of cofactors and their related electron transport proteins, has ensured that preparative biocatalytic hydroxylations are most usefully performed with whole-cell catalysts. The exceptions to this generality, the lipoxygenases and haloperoxidases, will be considered in Sec. n.B. 

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