P3-Adrenergic receptor agonist

Fletcher DS, Candelore MR, Grujic D, et al. P3 Adrenergic receptor agonists cause an increase in gastrointestinal transit time in wild-type mice, but not in mice lacking the p3 adrenergic receptor. J Pharmacol Exp Ther 1998 287 720-724. 

Reported bioanalytical applications that use SS-LLE products include both tlie cartridge (tube) format and the microplate format. Some of these applications include the determination of mexiletine [44], amiodarone [45] and other antiarrhythmic drugs [46], proxyphylline [47], 16(3-hydroxystanozolol [48], dextromethorphan [49], and simvastatin [50] from biological fluids. Microplate applications for SS-LLE include a crude purification of crude combinatorial library samples [51], carboxylic acid-based matrix metallo-protease inhibitors [52], and a p3-adrenergic receptor agonist [53]. 

Antiatherosclerotics pK 4,5 P3 Adrenergic receptor agonist hepatitis C virus... 

A more appealing feature is that one-pot synthesis of chiral styrene oxides can be performed by sequential asymmetric reduction of chloroacetophenones with the chiral Rh in 2-propanol followed by treatment of the reaction mixture with NaOH aqueous solution, leading to the desired products in isolated yields of 80-90% with 96-98% ee in a single reactor (Fig. 7) [37]. For example, (5)-w-chlorostyrene oxide, which is a key intermediate for the preparation of several p3-adrenergic receptor agonist compounds, is easily obtained from a one-pot procedure. 

A chiral intermediate for the s)mthesis of p3-Adrenergic receptor agonist (PSAA) was prepared by the reduction of bromoketone (P3AA1) with Sphingomonas paucimobilis SC 16113 to the corresponding (l )-alcohol (P3AA2) in 85% yield with 99.5% ee (Figure H.lOg) [64],... 

P3-adrenergic receptor Altered leptin and insulin concentrations after agonist treatment [66]... 

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