Ozonolysis reactions microreactor

The much larger rates of heat transfer in microreactors allow highly exothermic reactions that are difficult to control in conventional batch systems, such as direct fluorination (Chambers and Spink 1999 Jah-nisch et al. 2000 de Mas et al. 2003) and ozonolysis (Wada et al. 2006). Thus, microreactors expand the number of possible reactions and feasi-... 

A multistep gas-liquid process using a falling-film microreactor was carried out for the ozonolysis of a steroid that is a fast and highly exothermic reaction [50],... 

Another concept of packed bed microreactor systems are the Thales Nano continuous-flow reactors [96]. They are meant for hydrogenation (H-cube) and ozonolysis (0-cube) reactions. The catalyst is packed inside the reactor in a form of... 

In 2007, Steinfeldt et al. [34] utilized a falling film microreactor by IMM (www.imm-mainz.de) for studying the ozonolysis of acetic 1-vinyl-hexyl ester (63) in dichloromethane as a solvent. In order to determine the influence of reaction parameters (e.g., temperature, ozone partial pressure, and reactant concentration) on the product distribution, no reductive or oxidative treatment was applied. The reaction was studied in a temperature range from —50 to 0°C. Based on the obtained results, the mechanism shown in Figure 6.32 was suggested. 

In 2010, the authors described the ozonolysis of 1-decene (61) in different solvents (dichloromethane, methanol, and a mixture of both) [35]. Results obtained in the falling film microreactor were compared to those obtained in a semibatch reactor with continuous ozone dosing to the reaction mixture. The reaction mechanism and the assumed species in the reaction mixture are summarized in Figure 6.33. 

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