Oxytricha trifallax

Does the assumption of the mutator phenotype of the individual cancer cell in a multicellular host constitute a regression to the level of the ancestral unicellular eukaryotes, which were driven by TEs (transposases, retrotransposons, retroviruses), that invaded their genome, and existed there transcribed into mutator DNA sequences The ciliate Oxytricha trifallax possesses a somatic macronucleus and a diploid germline micronucleus [2094]. In the macronucleus reside innumerable... 

Williams KR, Doak TG, Herrick G. Telomere formation on macronuclear chromosomes of Oxytricha trifallax and O. fallax alternatively processed regions have multiple telomere addition sites. BMC Genet > v.3 2002. doi 10.1186/1471-2156-3-16. 

Cavalcanti AR, Dunn DM, Weiss R, Herrick G, Landweber LF, Doak TG. Sequence features of Oxytricha trifallax (class Spirotrichea) macromolecular telometric and subtelometric sequences. Protist. 2004 155 311-22. 

Sedwick C. Anna Akhmanova great tips on microtubules. J Cell Biol. 2011 195 168-9. Bryan TM, Sperger JM, Chapman KB, Cech TR. Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Proc Natl Acad Sci USA. 1996 95 8479-84. 

Zahicr AM, Neeb ZT, Lin A, Katzman S. Mating of the stichotrichous ciliate Oxytricha trifallax induces production of a class of 27 nt small RNAs derived from the parental micronucleus. PLoS One. 2012 7(8) e42371. 

Witherspoon DJ, Doak TG, Williams KR, Seegmiller A, Seger J, Herrick G. Selection on the protein-coding genes of the TBEl family of transposable elements in the ciliates Oxytricha fallax and O. trifallax. Mol Biol Evol. 14 696-706. 

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