Oxytocin desamino

Oxytocin is used in obstetrics to induce labor, e.g. to maintain the uterine contractions during birth, and to promote the evacuation of milk. The most important therapeutic use of vasopressin is based on its antidiuretic effect in diabetes insipidus (e.g. l-desamino-D-Arg8-vasopressin as a nasal spray92 ). 

De Groot, A.N.J.A., Hekser, Y.A., Vree, T.B., and van Dongen, P.W.J. (1995) Oxytocin and desamino-oxytocin tablets are not stable under simulated tropical conditions, J. Clin. Pharm. Ther., 20, 115-119. 

We successfully used electro-deprotection reactions in the synthesis of various classes of natural compounds, such as amino acids, oligopeptides, glycoproteins, phospholipids, saccharides, polysaccharides, etc. [279-283]. Application of the method instead of chemical synthesis of oxytocin and desamino-oxytocins led, for example, to a twofold increase in the yield of these hormones with high degree of hormonal activity (joint work with the Riga s chemists [284]). 

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