Oxytetracycline clearance

The effect of experimentally induced bacterial infections, all of which have in common the presence of fever, on the disposition of various antimicrobial agents in pigs is presented in Table 3.1. In the infected pigs, the apparent volume of distribution of penicillin G, ampicillin and, to a lesser extent, trimethoprim is increased, of enrofloxacin and sulphonamides remains unchanged, and of oxytetracycline is decreased. The systemic clearance of penicillin G, ampicillin and trimethoprim is increased, of sulphamethoxazole and sulphadimethoxine remains unchanged, and of sulphadimidine,... 

Mevius DJ, Vellenga L, Breukink HJ, Nouws JFM, Vree TB, Driessens F, Pharmacokinetics and renal clearance of oxytetracycline in piglets following intravenous and oral-administration, Vet. Quart. 1986 8 274-284. 

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