Oxygenases, Rieske-type

Sequences of proteins containing Rieske-type clusters have been deduced from the complete operons of several dioxygenases these dioxygenases require electrons from NAD(P)H to convert aromatic compounds to cis-arene diols. The water-soluble dioxygenase systems consist of a reductase and a terminal dioxygenase many dioxygenases also contain a [2Fe-2S] ferredoxin (20). The terminal oxygenases contain a Rieske-type cluster and the ferredoxins may contain either a Rieske-type or a 4-cysteine coordinated [2Fe-2S] cluster. 

Proteins from Eukaryotes that Show Homology to Bacterial Rieske-Type Oxygenases... 

Pruzinska A, Tanner G, Anders I, Roca M, Hortensteiner S (2003) Chlorophyll Breakdown Pheophorbide a Oxygenase is a Rieske-type Iron-sulfur Protein, Encoded by the Accelerated Cell Death 1 Gene. Proc Natl Acad Sci USA 100 15259... 

Dioxygenases are nonheme Rieske-type NAD(P)H-dependent enzymes that introduce both atoms of molecular oxygen into their substrates. The multicomponent enzyme systems are composed of a catalytic oxygenase component and one- or two-electron transfer proteins, including a flavoprotein reductase, and in some cases a ferredoxin that mediates electron transfer from the reductase to the oxygenase component ([3] Figure 17.1). 

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