Oxygen sensing pathways

Koivunen P, Hirsila M, Gunzler V, Kivirikko KI, Myllyhaiju J. Catal)4ic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. J. Biol. Chem. 2004 279 9899-9904. 

Ehleben W, Bolling B, Merten E, Porwol T, Strohmaier AR, et al. 1998. Cytochromes and oxygen radicals as putative members of the oxygen sensing pathway. Resp Physiol 114 25-36. 

Porwol T, Ehleben W, Zierold K, Fandrey J, Acker H. The influence of nickel and cobalt on putative members of the oxygen-sensing pathway of erythropoietin-producing HepG2 cells. Eur J Biochem 1998 256(l) 16-23. 

Ehleben W, Porwol T, Fandrey J, Kummer W, Acker H. Cobalt and desferrioxamine reveal crucial members of the oxygen sensing pathway in HepG2 cells. Kidney Int 1997 51(2) 483 9I. 

Daghman NA, Elder GE, Savage GA, Winter PC, Maxwell AP, Lappin TR. Erythropoietin production evidence for multiple oxygen sensing pathways. Ann Hematol 1999 78(6) 275-278. 

Safran, M., and Kaelin, W.G., Jr. (2003) HIE hydroxylation and the mammalian oxygen-sensing pathway. Journal of Clinical Investigation, in, 779-783. 

Webster, K.A., D.J. Discher, O.M. Hernandez, K. Yamashita, and N.H. Bishopric (2000). A glycolytic pathway to apoptosis of hypoxic cardiac myocytes. In Oxygen Sensing and Molecule to Man. Advances in Exptl. Medicine and Biology pp. 161-176, 475, ed. S. Lahiri, N.R. Prabhakar, and R.E. Forster, II. New York Kluwer Academic/Plenum. 

Acute high-altitude studies of both human and animal models indicate that hypoxia defenses are initiated by several oxygen sensing, signal transduction pathways. For convenience, these have been summarized as five general hypoxia response systems (figure 5.2(A)-(E) ... 

The role of ascorbate, NO, and ROS, as well as other cellular factors, in oxygen sensing is not yet fully clear and requires more investigation. Additionally, other signaling pathways could likely be integrated with HIF regulation as indicated by studies showing that in HIF-la, Thr-796 phosphorylation blocks Asn-803 hydroxylation by FIH (107). 

Members of the a-ketoglutarate-dependent dioxygenase family are involved in a number of biosynthetic pathways, and have recently been implicated in mammalian oxygen sensing by hypoxia inducible factor (HIF), via hydroxylation of Pro-402, Pro-564, and Asn-803 of HIF-la. ... 

Reduction of the asparagine s hydroxylase reaction allows the HIFa to do its job, and reduction of the prolyl hydroxylase reaction stops degradation of the HIFa by the ubiquitin-linked pathway. Many researchers believe that these two reactions are the mechanism for oxygen sensing, but others believe they are just incidental to the true mechanism, which has yet to be discovered. 

Bonnet, S., Michelakis, E.D., Porter, C.J., Andrade-Navarro, M.A., Thebaud, B., Bonnet, S., Haromy, A., Harry, G., Moudgil, R., McMurtry, M.S., Weir, E.K., and Archer, S.L. (2006) An abnormal mitochondrial-hypoxia inducible factor-lalpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats similarities to human pulmonary arterial hypertension. Circulation 113,2630-2641. 

In humans, the enzyme that puts oxygen onto collagen fibers. .. C. Loenarz et al. The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the... 

Srinivas V, Leshchinsky I, Sang N, King MP, Minchenko A, Caro J. Oxygen sensing and HlF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway. J Biol Chem 2001 276(25) 21995-21998. 

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