Oxygen equilibrium curves

Fiaure 14, Oxygen equilibrium curves of freshly coveted blood samples from the author (A) and from a patient with Hh Fort Gordon with an increased oxygen Mnity (B), Hb Fort Gordon has been identified as agfit (145 Tyr Asp). 

Fig. 8. Oxygen equilibrium curves of caiman and horse hemoglobin with and without C02. C0] = 40Torr, 25°C, I = 0.2 M, pH 7,2 for caiman (60), pH 7.4 for horse (104).

Selected entries from Methods in Enzymology [vol, page(s)] Computer programs, 240, 312 infrared S-H stretch bands for hemoglobin A, 232, 159-160 determination of enzyme kinetic parameter, 240, 314-319 kinetics program, in finite element analysis of hemoglobin-CO reaction, 232, 523-524, 538-558 nonlinear least-squares method, 240, 3-5, 10 to oxygen equilibrium curve, 232, 559, 563 parameter estimation with Jacobians, 240, 187-191. 

Fig. 53. Oxygen equilibrium curves of cross-linked mixed-valency hybrid hemoglobin (a + CN3)A(ap)cXL, in 0.1 M phosphate plus 2 mM KCN at various pH values. (A) Hill plots (B) 02 binding constants. [From Miura et al. (1987)].

SirtI C, Laubenthal H, Zumtobel V et al 1999 Tissue deposits of hydroxyethyl starch (HES) dose-dependent and time-related. British Journal of Anaesthesia 82 510-515 Smale K, Anderson L S, Butler P J 1994 An algorithm to describe the oxygen equilibrium curve for the thoroughbred racehorse. Equine Veterinary Journal 26 500-502... 

Figure 1 Carotid chemoreception activities plotted against Pq resemble Hb-02 dissociation curves. Oxygen equilibrium curves (SO2 %) corresponding to activity of carotid chemo-receptors at three measurements of arterial Pco and pH plotted against arterial Pq. The maximal activity at pHa 7.25 and Pa02 of 25torr was taken as 100% desaturation of a hypothetical heme-containing ehromophore group. The curves resemble O2 equilibrium curves of a polymeric ehromophore group with a Bohr effect (1).

It is pertinent in this connection to observe that when hemoglobin is partly-oxidized the oxygen equilibrium curve becomes more nearly hyperbolic (i.e., n decreases) and is shifted to the left (i.e., py, decreases) corresponding to an increase of oxygen afiSnity (38.1). 

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