Oxygen convulsions

Ventilate the patient. There may be an increase in airway resistance due to constriction of the airway and the presence of secretions. If breathing is difficult, administer oxygen. As soon as possible administer of atropine alone or in combination with pralidoxime chloride (2-PAMC1) or other appropriate oxime. Diazepam may be required to prevent or control severe convulsions. If diazepam is not administered within 40-minutes postexposure, then its effectiveness at controlling seizures is minimal. 

In rats, when dichlorodifluoromethane was administered at various concentrations with 20% oxygen for 30 minutes, the following effects were observed 2 00,000 ppm, no observable effects 300,000ppm, muscular twitching and tremor 800,000 ppm, coma, corneal reflexes absent 800,000 ppm for 4 and 6 hours was not lethal and the animals suffered no permanent effects. In a recent report 3- to 20-minute exposure of rats to concentrations of 140,000-470,000 ppm induced in a dose-dependent manner acute neurobehavioral effects ranging from operant performance deficits, to motor and equilibrium deficits, to anesthesia with occasional convulsions. ... 

Concentrations of oxygen in the inspired air of 12-16% cause tachypnea, tachycardia, and slight incoordination. Air containing 6-10% oxygen causes nausea, lethargic movements, and unconsciousness breathing less than 6% oxygen produces convulsions, followed by apnea and cardiac arrest. ... 

Given intravenously, both diazepam and midazolam are effective first-line treatments for status epilepticus. It is essential to be aware that the large doses that may be necessary to control convulsions are likely to cause respiratory depression and obtund protective reflexes. Oxygen and equipment suitable for its administration should be available. For intractable status epilepticus, clonazepam is a longer-acting alternative which can also be given by intravenous infusion. Overdosage... 

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