Pregabalin Oxycodone

Oxycodone/Lorazepam/Ethanol Multiple oral doses of pregabalin were coadministered with oxycodone, lorazepam, or ethanol. Although no pharmacokinetic interactions were seen, additive effects on cognitive and gross motor functioning were seen when pregabalin was coadministered with those drugs. 

There appears to be no pharmacokinetic interaction between pregabalin and carbamazepine, gabapentin, lamotrigine, phenobarbital, phenytoin, topiramate, valproate, alcohol, lorazepam, or oxycodone. However, the impairment of cognitive and gross motor function caused by oxycodone was additive with pregabalin, and pregabalin may potentiate the effects of alcohol and lorazepam. 

The manufacturer notes that there was no clinically relevant pharmacokinetic interaction between pregabalin and oxycodone, and that there was no clinically important effect on respiration. However, pregabalin appeared to cause an additive impairment in cognitive and gross motor function when given with oxycodone. This suggests caution is warranted during combined use. 

Gatti A, Sabato AF, Occhioni R, Colini Baldeschi G, Reale C. Controlled-release oxycodone and pregabalin in the treatment of neuropathic pain results of a multicenter Italian study. Fur Neurol 2009 61(3) 129-37. 

Pregabalin The combination of controlled-release oxycodone with pregabalin reduced the incidence of somnolence associated with oxycodone in 169 patients compared with 106 on oxycodone alone [145 ]. 

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