Oxycodone contraindications

Opioids and derivatives (e.g., meperidine, butorphanol, oxycodone, hydromorphone) provide effective relief of intractable migraine but should be reserved for patients with moderate to severe infrequent headaches in whom conventional therapies are contraindicated or as rescue medication after failure to respond to conventional therapies. Opioid therapy should be closely supervised. 

Oxycodone is nearly 10 times as strong as codeine, with absorption equal to that of orally administered morphine. Neither hydromorphone nor oxycodone is approved for use in children, and hydromorphone is contraindicated in obstetrical analgesia and in asthmatics. 

Consider other NSAIDs or COX-2 inhibitors (it not contraindicated) or oral oxycodone (Roxicodone), morphine (Duramorph), or advance to higher level of care (parenteral analgesia and/or pain-management specialist). 

True allergy to opioids is rare. Hypersensitivity to oxycodone or its non-opioid component in a combination product is an absolute contraindication. 

Absolute contraindications for both opioids and NSAIDS include hypersensitivity reactions, such as development of shortness of breath, severe rash, etc. Oxycodone and hydrocodone are contraindicated in patients with risk for significant respiratory depression. Because of the inhibition of GI motility by narcotic medications, oxycodone and hydrocodone are contraindicated in the setting of paralytic ileus. 

Absolute OxyContin is contraindicated in patients with known hypersensitivity to oxycodone, or in any situation where opioids are contraindicated. OxyContin is contraindicated in any patient who has or is suspected of having paralytic ileus. 

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