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8-oxoguanine adenine paired with

Both NER and BER forms of excision repair remove a great variety of defects, many of which are a result of oxidative damage.657 720 Most prominent among these is 7,8-dihydro-8-oxoguanine (8-OG), which is able to base pair with either cytosine (with normal Watson-Crick hydrogen bonding) or with adenine, which will yield a purine-purine mismatch and aC G —> A T transversion mutation (Eq. 27-24), a frequent mutation in human cancers.721 722... [Pg.1582]

Figure 2836 Oxoguanine-adenine base pair. When guanine is oxidized to 8-oxoguanine, the damaged base can form a base pair with adenine through an edge of the base that does not normally participate in base-pair formation. Figure 2836 Oxoguanine-adenine base pair. When guanine is oxidized to 8-oxoguanine, the damaged base can form a base pair with adenine through an edge of the base that does not normally participate in base-pair formation.
A.K. Singh et al., Mismatch base pairing of the mutagen 8-oxoguanine and its derivatives with adenine A theoretical search for possible antimutagenic agents. Int. J. Quantum Chem. 102, 343-351 (2005)... [Pg.438]

See other pages where 8-oxoguanine adenine paired with is mentioned: [Pg.233]    [Pg.805]    [Pg.142]    [Pg.334]    [Pg.167]    [Pg.167]    [Pg.167]    [Pg.11]    [Pg.305]   
See also in sourсe #XX -- [ Pg.15 ]



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8-Oxoguanine

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