4-oxo-2-phenyl-3,4-dihydro

Et2NH (25 mL. large excess) was cautiously added to a cooled stirred suspension of crude 5-oxo-4-phenyl-4,5-dihydro-l//-l,2,4-benzotriazcpine-3-carbonyl chloride (10, R1 = Ph, R2 = H 5.0 g, 17 mmol) in benzene (100 mL) below 25 C and stirring was continued for 2h. H20 was added to dissolve the F,t2NH HOI formed and the insoluble yellow residue, A%V-diethyl-5-oxo-4-phenyl-4,5-dihydro-l//-l,2,4-benzodiazepine-3-carboxamide (llg) was collected, washed with H20 and recrystallizcd (95% EtOH) yield 4.0 g (70%) mp 202-204 C. [Pg.461]

A similar reaction of 5-oxo-4-phenyl-4,5-dihydro-l//-l,2.4-bcnzotriazepine-3-carbonyl chloride with 2-(dimethylamino)ethanol gave 2-(dimcthylamino)elhyl 5-oxo-4-phenyl-4,5-dihydro-l U-, 2,4-benzotri-azcpine-3-carboxylate (11c) yield 54% mp 130-132 C. [Pg.461]

Die Beliehtung von Sydnonen licfert 1,2,3-Triazole und/oder 5-Oxo-4,5-dihydro-l, 3,4-oxadiazole. Bei der Beliehtung von 3-Phenyl-sydnon erhalt man als Hauptprodukt 5-Oxo-4-phenyl-4,5-dihydro-1.3 A-oxadiazot -. [Pg.402]

Hydroxy-2-oxo-3-phenyl-2,5-dihydro- VI/2, 688 4-Hydroxy-5-oxo-4-phenyl-4,5-dihydro- X/4, 839 Keten Methoxycarbonyl-phenyl-VII/4, 81, 90... [Pg.711]

Analog erhalt man aus 5-Oxo-2-phenyl-4,5-dihydro-1,3-oxazol 2-Benzoylamino-athanol5 (88% d.Th.) und mit Lithiumalanat aus 5-Oxo-4-methyl-2-benzyliden-2,5-dihydro-1,3-oxazol 2-Phenylacetylamino-propanol (30% d.Th.)6. Calciumboranat reduziert 5-Oxo-2-phenyl-4-benzyliden-4,5-dihydro-1,3-oxazol zu oc-Benzoylamino-zimtal-kohol1. [Pg.228]

Zu 6,38 g (23,7 mmol) 4,4-Bis-[2-methyl-allyl]-5-oxo-2-phenyl-4,5-dihydro-1,3-oxazol in 30 ml Methanol wird eine Losung von 6,00 g (149,6 mmol) Nalriumhydroxid in 25 ml Methanol/Wasser (2 3 Vol.) unter Eiskiihlung getropft. Man riihrt 2d bci 25° (Umsatzkontrolle durch DC), zieht das Methanol ab und uckstand aus F.ssigsaure-ethylester umkristallisiert Ausbeute 5,65 g (83%) Schmp. 183-185°. [Pg.411]

H-1, 2,3-Triazol 4-Hydroxy-2-phenyl- E8d, 357 (1-Oxid-Red.) 111-1,2,4-Triazol 5-Oxo-3-phenyl-4,5-dihydro- X/2, 159... [Pg.465]

Pyrazin 3-Amino-2-cyan-5-(2-furyi)-E9b/2, 31 If. (N-Oxid-Red.) lH-Pyrazol 4-Diazo-5-oxo-3-phenyl-4,5-dihydro- X/4, 525/ El4b, 1114 (Amin 4- NaN02) lH-(Pyrimido 5,4-f]indazol) 5(bzw. 9)-Hydroxy- E8b, 849 (Pyrimidin-Ringschl.)... [Pg.575]

Furan 5-Oxo-2-phenyl-4,5-dihydro-VI/2, 614f. (decarboxyl. Cycli-sier.) E5, 735 (Cycloadd.) Naphthalln... [Pg.711]

Phthalazine l,4-Dihydroxy-5(or 6)-dimethylamino- E9a, 752 (subst. Phthalanhydrid/N2H4) lH-PyrazoI 5-Methyl-5-nitro-4-phenyl-4,5-dihydro- X/l, 426 Pyrido[2,3-d]pyrimidin 4-Hydroxy-2-oxo-l-propyl-1,2-dihydro- E9c,... [Pg.745]

Phenol 2.6-Bis-[thiocyanatomethyl]-4-methyl- IX, 859 lH-Pyrazol 4-Dithiocarboxy-3-methyl-5-oxo-l -phenyl-4,5-dihydro- E5, 897 (H - CSSH)... [Pg.855]

The investigations (66JCS(C)2290) on the reactivity of this ring system have centered around 5-oxo-3-phenyl-4,5-dihydro-[l,2,3]triazolo[l,5-fl]quinazoline (see Scheme 17) whose preparation is given in Section 4.15.4.6.4. The latter two reactions in Scheme 17 resemble those discussed previously for [l,2,3]triazolo[l,5-a]pyrimidines and depicted in Scheme 12. [Pg.876]

A representative of this ring system (namely, 5-oxo-3-phenyl-4,5-dihydro[l,2,3]triazolo[l,5-a jquinazoline (335)) has been prepared by the reaction between o-azidobenzoic acid and phenylacetonitrile in the presence of sodium methoxide (66JCS(C)2290). This is illustrated in Scheme 57. [Pg.895]

Diphenyl-3-methyl-3-(4-melhyl-5-oxo-2-phenyl-4,5-dihydro-l,3-oxazol-4-yl)- 2846, 3149... [Pg.3386]

Werden als Kondensationsmittel fur a-Thiocarbonylamino-carbonsaure-Derivate Carbonsau-reanhydride verwendet, kann es zu einer nachtraglichen O-Acylierung kommen. So handelt es sich bei einer Reihe von Produkten, die aus a-Thiobenzoylamino-carbonsauren und Acelan-hydrid erbalten wurden, nicht wie angegeben691 um 5-Oxo-2-phenyl-4,5-dihydro-l,3-thiazole, sondern um 5-Acetoxy-2-phenyl-l, 3-thiazole690. [Pg.122]

Die aus N-Acyl-a-aminosauren leicht zuganglichen 5-Oxo-2-phenyl-4,5-dihydro-1,3-oxazole (Azlactone) reagieren mit Oximen zu O-Acyl-oximen ... [Pg.781]

Haufig wird diese Methode in ihrer Anwendbarkeit durch schwer abzutrennende Neben-produkte eingeschrankt. Eine elegante Variante, bei der die Nebenprodukte leicht abzu-trennen sind, nutzt die gemischten Carbonsaure-Kohlensaure-Anhydride, die aus Chlor-ameisensaure-ethylester und der N-Acyl-a-aminosaure gut zuganglich sind. So wird das 5-Oxo-2-phenyl-4,5-dihydro-l, 3-oxazol (80%) nach dieser Methode aus Benzoylamino-es-sigsaure (Hippursaure) hergestellt69. Besonders empfohlen wird diese Methode, wenn die Azlactone nur in situ prapariert warden so lien. [Pg.822]

Transformation of alkyl (5-oxo-l-phenyl-4,5-dihydro-l/-/-pyrazol-3-yl)acetates into 5-heteroaryl-3-oxo-2-phenyl-3,5-dihydro-2H-pyrazolo[4,3-c]pyridine-7-carboxylates (03H197)... [Pg.150]

Compound 19 was prepared from ethyl (5-oxo-l-phenyl-4,5-dihydro-lH-pyrazol-3-yl)acetate (12) and 2 equivalents of DMFDMA in DMF in... [Pg.151]

A methanolic soln. of 4-[(chromon-3-yl)methylene]-5-oxo-2-phenyl-4,5-dihydro-l,3-oxazole refluxed 45 min. in the presence of anhydrous Na-carbonate 2-meth-oxycarbonyl-4-(2-hydroxybenzoyl)pyrrole. Y 74%. F. e., also thiophene analogs, s. A. O. Fitton et al.. Synthesis 1977, 133. [Pg.411]

Methyl-5-oxo-l-phenyl-4,5-dihydropyrazol-4-ylidene)-2,3-dihydro-l//-azepine (3), formed in 62% yield by the condensation of 2-amino- or 2-butoxy-37/-azepine with 3-methyl-l-phenylpyrazol-5(4//)-one, with Meerwein s reagent yields the tetrafluoroborate salt 4 which, on treatment with sodium dihydrogen phosphate, liberates the free base 5.64... [Pg.160]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...