Oximes bisquaternary

Musilek, K., Komloova, M., Holas, O., et al., 2011b. Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-l,3-diyl linkage-preparation, in vitro screening and molecular docking. Bioorg. Med. Chem. 19, 754-762. 

Ashani Y, RadicZ, Tsigelny letal.( 995). Amino acid residues controlling reactivation of organophos-phonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes../ Biol Chem, 270, 6370-6380. 

Luo C, Ashani Y and Doctor BP (1998a). Acceleration of oxime-induced reactivation of organophosphate -inhibited fetal bovine serum acetylcholinesterase by monoquaternary and bisquaternary ligands. Mol Pharmacol, 53, 718-726. 

The current standard treatment with reactivators includes different types of oximes with a similar basic structure differing by the number of pyridi-nium rings and by the position of the oxime group in the pyridinium ring. From the common oximes, mono- and bisquaternary pyridinium oximes are frequently used, such as pralidoxime, obidoxime, trimedoxime, methoxime,... 

FIGURE 72.15 Monoquaternary and bisquaternary oximes prepared by Musilek et al. (2006b,c). 

Lundy, P.M., Raveh, L., Amitai, G., 2006. Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning. Toxicol. Rev. 25, 231-243. 

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