Reaction engineering oxidoreductases

Recently, it has been shown that there are NAD-dependent oxidoreductases that will not liberate NADH/NAD+ from the active site. They catalyse such redox reactions, albeit not with formate but with less favourable electon donors and with low rates [9]. When these enzymes can be properly engineered and produced, they will impose few constraints on the reactor design. This situation is analogous to what has been described in the previous section for synthetic reactions using hydrolases if a biocatalyst is found that can directly convert the substrates into the desired products, without formation of intermediates or occurrence of side-reactions, the reactor design becomes simple. 

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