Oxidative stress from redox-active metals

To date, there is no generally accepted theory that accounts for the development of AD pathology. The multifactorial basis of the disease makes such a theory unlikely to be possible in the foreseeable future. In addition to the NFTs and amyloid-hypothesis of the disease, oxidative stress, systemic levels of redox active metal ions, cardiovascular disease, the apoEe4 allele and type 2 diabetes are all clear risk factors for development of AD. However, recent research supports the notion that the Ap buildup may be a key event in AD and that other manifestations of the disease, like NFT formation, result from an imbalance between AP production and AP clearance (17). 

---