Oxidative polymorphism, poor extensive metabolizers

Defective oxidation. Variation in response to some drugs can be attributed to genetic polymorphisms involving oxidation of their carbon centres (see Metabolism p. 112). The condition was recognised by abnormal metabolism and response to a standard dose of debrisoquine. Individuals may be classed as extensive or poor oxidisers and the latter are at special risk of adverse effects from drugs whose inactivation is strongly dependent on the defective... 

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