Oxidation of Prostanoids

Since the initial report of in vivo w-l hydroxylation of prostanoids in 1966 u)- and to-l 

4A5 Rabbit p/q)-1 oxidation of laurate and palmitate, some p-oxidation of PGAj and arachidonate 

4A6 Rabbit (p-oxidation of laurate, palmitate, and arachidonate. Low PGA (p-oxidation 

A special case is that of rabbit lung CYP4A4, an isoform induced during pregnancy -and active in the op-hydroxylation of several prostanoids, including PGEj (Table 11,1) ° As with AA, none of the CYP4A isoforms characterized to date is selective for the p-1 carbon of prostanoids (Table 11.1) ° A more spe- 

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