Oxazolines Etoxazole

During its oxazoline chemistry program Yashima discovered the high acaricidal activities of 2,4-diphenyl-l,3-oxazolines of structure type shown in Table 26.2.9 

Apple European red mite (P. uhni) Two spotted spider mite (Tetranychus urticae) 3.0-5.0 

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The oxazoline etoxazole (45 1998, Baroque , Yashima/Sumitomo) [106] is an acaricidal IGR (Chapter 26.2) and also possess the 2,6-difluorophenyl moiety like 46 and the BPU class (Fig. 35.11). 

The well-known insecticidal benzoyl phenyl ureas (BPUs), exemplified by diflubenzuron, are chitin biosynthesis disrupters, but at an uncharacterized site distinct from chitin synthase (2), Figure 1. The related bridge-cyclized oxazoline chemistries from DuPont and Yashima, represented by etoxazole, are also commercial or near-conunercial insecticides with the same mechanism of action (5), Figure 1. 

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