Oxalic monoamide

Hofmann amine separation org chem A technique to separate a mixture of primary, secondary, and tertiary amines they are heated with ethyl oxalate there is no reaction with tertiary amines, primary amines form a diamide, and the secondary amines form a monoamide when the reaction mixture is distilled, the mixture is separated into components. haf-mon am,en, sep-3,ra-sh3n ... 

Free-radical reactions. Silver nitrate, sodium persulfate, and iron(III) nitrate constitute an oxidizing system that degrades carboxylic acids to radicals. Adding these reactive intermediates to radical acceptors such as methyl vinyl ketone, acrylic esters, and acrylonitrile initiates synthetically useful processes. Monoamides of oxalic acid undergo oxidative degradation by (NH )2SjOg in the presence of AgNOj-Cu(OAc)2 to afford isocyanates in a biphasic system (11 examples, 45-87%). ... 

Petasis reagent was also effective for the methylenation of aldonolactones, 96" and 98."" Petasis olefmation of unsymmetrical oxalates and oxalate monoesters or monoamides 100 under microwave-assisted, provides pyruvate-based enol ethers and enamines 101 in higher yields... 

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