Oxadi azoles

Hydroxy-3- (4-methyl-phenyl) -1,2.4-oxadi-azol Schmp. 223°. ..-1,2,4-lhiadiazol Schmp. 218°... 

Cl1H13N5O5, trans-5-Amino-3-(2-(5-nitro-2-furyl)vinyl)-1,2,4-oxadi-azole - N,N-dimethylformamide, 43B, 779 C11H15I2N5, 9-Cyclohexyladenine - iodine, 39B, 440 C,iH,gN403, Imidazole - 5,5-diethylbarbituric acid (1 1), 40B, 551 Cl1H17BrN207, 5-Bromouridine - dimethylsulfoxide, 32B, 272 C11H19NO6, Glucitol - pyridine, 37B, 342... 

A set of heterocyclic ketones including 1,3,4-oxadi azole-linked compounds were synthesized via a dehydrative cyclization using the Burgess reagent in a single-mode microwave <2003BML3909>. 

Beim kurzen Erhitzcn in waBriger Natronlauge dehydratisiert 3-Amino-2-(amino-benzoyloxi-mino-methyl)-pyrazin in guter Ausbeute zu 3-(3-Amino-2-pyrazinyl)-2-phenyl-l,2,4-oxadi-azol (77% Schmp, 220-2230)211 ... 

Those compounds with three heteroatoms (one oxygen and two nitrogen) are the 1,2,3-oxadiazoles (87), 1,2,4-oxadiazoles (88), 1,2,5-oxadiazoles (89), and 1,3,4-oxadiazoles (90) (Scheme 33). The 1,2,5-oxadi-azoles are also known as furazans 1,2,3-oxadiazoles include the sydnones. 

Macaev F, Rusu G, Pogrebnoi S et al (2005) Synthesis of novel 5-aryl-2-thio-l,3,4-oxadi-azoles and the study of their structure-anti-mycobacterial activities. Bioorg Med Chem 13 4842-4850... 

Hydrazonoyl halide 325 reacted with 2-methylthiobenzimidazole 324 to furnish benzimidazo[l,2-<7]-l,2,4-oxadi-azole derivative 326 (Scheme 77) <2004HAC432>. This reaction proceeded in a [24-3] fashion. 

Attempts55,56 to synthesize 5-substituted 3-phenylthioureido-l,2,4-oxadi-azoles (77) by reaction of 3-amino-l,2,4-oxadiazoles (76) with phenylisothio-cyanate directly furnished 3-acylamino-5-anilino-l,2,4-thiadiazoles (78), the rearrangement products derived from 77 which underwent a fast mhr55,56 under the experimental conditions. 

Platinum complexes. From di[2,5-diphenyl-l,3,4-oxadiazole-C-2"Al-3]-platinum(ll) doped PVK devices with greenish-yellow electrophosphorescence could be obtained. A blend of PVK and PBD was used as the host matrix and a bicyclic platinum complex containing the 1,3,4-oxadi-azole moiety in 2% doping concentration was added. No emission from either PVK or PBD was observed in the devices. 

Modified polymers of PPV with pendent carbazol groups and oxadi-azole groups have been prepared by direct polymerization of the respective a, a-dibromo-p-xylene monomers. " ... 

A soln. of 5-nitro-2-furohydroxamic chloride and 2 moles of ethyl iminobenzoate in dry ether allowed to stand several hrs. until the resulting iminoether hydrochloride is completely precipitated 3-(5 -nitro-2 -furyl)-5-phenyl-l,2,4-oxadi-azole. Y 80%, F. e. s. F. Eloy and R. Lenaers, Bl. Soc. chim. Belg. 72, 719 (1963). 

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