Overview of Nucleotide Metabolism

All organisms synthesize, interconvert, and catabolize various purine and pyrimidine nucleotides. However, cells of different types, or even the same cells in different stages of development, differ greatly in their ability to carry out some of the reactions involved, with some cells favoring one set of reactions and others another. In the rest of the chapter we deal with the details of these reactions. 

Purine nucleotides can be synthesized in three ways By de novo synthesis, by reconstruction from purine bases through the addition of a ribose phosphate moiety, or by phosphory- 

The formation of PRPP from ribose-5-phosphate and ATP is catalyzed by ribose-5-phosphate pyrophosphokinase (fig. 23.7). This is an unusual kinase because the pyrophos-phoryl group is transferred rather than the phosphoryl group. 

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Overview of Nucleotide Metabolism Synthesis of Purine Ribonucleotides de Novo... 

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