Overview and Rationale of the SPMD-Toxicity Screening Approach

OVERVIEW AND RATIONALE OF THE SPMD-TOXICITY SCREENING APPROACH 

Ko l et al. (2003) developed the Vtox approach for assessing the relative toxicity of SPMD extracts. They defined Vtox(50) as the media volume that is needed to reduce the toxicity of the extract of a 1-day exposed standard SPMD to a 50% effect level. The following relationship is nsed to determine Vtox 

The following sections describe several commonly used bioassay tests that have been successfully used in conjunction with SPMDs. However, no attempt was made to cover all of the in vitro assays used for SPMD extracts. 

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