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Ototoxicity chloramphenicol

Local apphcation of chloramphenicol can cause hearing defects. Asymmetrical hearing loss with lowered perception of high tones has been documented after treatment of chronic bilateral otitis media with chloramphenicol powder (15). Propylene glycol is often used as a vehicle for chloramphenicol ear-drops, and ototoxicity may be due to chloramphenicol and/or propylene glycol, which is itself strongly ototoxic. Ototoxic effects can also occur after systemic drug administration (16). [Pg.707]

Iqbal SM, Srivatsav CB. Chloramphenicol ototoxicity. A case report. J Laryngol Otol 1984 98(5) 523-5. [Pg.712]

Morizono T, Johnstone BM. Ototoxicity of chloramphenicol ear drops with propylene glycol as solvent. Med J Aust 1975 2 634-638. [Pg.626]

Chloramphenicol is poorly soluble in water, and as a vehicle in chloramphenicol ear drops propylene glycol is often used. In animal experiments, both substances have shown to be strongly ototoxic if applied to... [Pg.211]

See other pages where Ototoxicity chloramphenicol is mentioned: [Pg.2484]    [Pg.2484]    [Pg.135]    [Pg.399]    [Pg.38]    [Pg.237]    [Pg.84]    [Pg.663]    [Pg.211]    [Pg.212]    [Pg.215]   
See also in sourсe #XX -- [ Pg.211 ]



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Ototoxicity

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