Other Tissue Engineering Applications

So far, polyanhydrides have only been approved by the FDA as a drug dehvery system commercially produced by Guilford. Chemotherapeutic agent BCNU (carmustine) loaded in poly(CPP-SA) 20 80 wafer (Gliadel ) was used for treating brain tumors [161,194,195], More applications in controlled release include eye disorder, local anesthetics, and anticoagulants [194], Further biocompatibility analyses need to be conducted for the use of polyanhydrides in other tissue engineering applications. 

Mostly due to its highly water-soluble nature and lack of mechanical stability, CS has been modified with or used along with other polymers for drug delivery and tissue engineering applications. Porous sponge of CS-chitosan was used for the delivery of platelet-derived growth factor... 

Polyanhydrides have been developed into various systems with mainly bone tissue engineering applications in mind. These polymers have mechanical strength much lower than that of bone but have been combined with other polymers, such as poly(imide)s, to resolve this problem. Polyanhydrides have been developed into photo-cross-linkable systems, based on dimethacrylated anhydrides, and also injectable systems, but little interest into these polymers with regard to tissue engineering has been taken in the recent past [82]. 

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