Other Strategies to Construct Biologically Active Compounds

3 Other Strategies to Construct Biologically Active Compounds 99 

Enzymes 1 and 2 show different enantiopreference, and ideally, different cofactor dependency (See also Chapter 11) 

Driven by the need of enhancing the atom economy of chemical transformations, continuous efforts have been focused on the development of (bio)catalytic methods that combine two or more processes in a one-pot multistep sequential or even in a cascade fashion (see also Chapter 11). Undoubtedly, these transformations present several advantages such as the use of less reagents and solvents, production of less 

The use of simultaneous but independent redox steps in one-pot, is another type of strategy to obtain valuable enantioenriched alcohols. Usually the setup of this strategy is challenging, since kinetics and thermodynamics of each step have to fit. In one example, Kroutil and coworkers achieved the concurrent iridium atalyzed 

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