Other preliminary precautions

The temperature of the adsorbent and vapor with which it is in equilibrium must remain constant during the measurement. With nitrogen as the adsorbate the coolant most often used is liquid nitrogen. The temperature of liquid nitrogen is dependent on ambient pressure and the presence of impurities in the liquid which tend to elevate the boiling point. The Clapeyron-Clausius equation can be used to calculate the change 

near the normal boiling point the temperature will change by 0.01 K when the equilibrium pressure changes by 0.86 mm of mercury. 

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In the other case, the preliminary precaution principle was respected regarding the evaluation of risk acceptability. For that, action values of dosimetric quantities Sr or, if need be, Er defined by the Directive (EUPC. 2004) were used. An rmcertainty related to the existence of athermal effects during the exposure to NIEMF was incorporated using the uncertainty factor UF = 10 and an rmcertainty related to the individual differences in sensitivity was incorporated in the form of the uncertainty factor UFsd = 2. 

The interaction between aspirin and omeprazole is not established. The balance of evidence suggests that omeprazole is unlikely to have an important effect on the pharmacokinetics and efficacy of aspirin. However, because of the uncertainty generated by the animal and preliminary clinical data, " it would be of benefit to confirm this in further studies. No clinically significant pharmacokinetic interactions have been identified between any of the other NSAIDs and PPIs cited here, and no special precautions are needed during concurrent use. For mention that valdecox-ib raises plasma levels of omeprazole see NSAIDs Parecoxib + Miscellaneous , p.l60. Note that omeprazole and other proton pump inhibitors are widely used in the management of the gastrointestinal complications of aspirin and NSAIDs. 

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