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Other Oligonucleotide Modifications Catalyzed by DNAzymes

In contrast, RNA ligation by DNAzymes has been well documented [81]. The first Ca or Mg -dependent system gave nucleophilic opening of the 2 -3 cyclic phosphate of one RNA strand by the 5 -hydroxyl group of the other, resulting in an [Pg.9]

Other modification reactions of (ohgo)nucleotides catalyzed by DNAzymes include kinase (5 -phosphorylation) [89-92], DNA capping [93], self-depurination [94], and RNA tagging [95]. [Pg.10]


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